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HANSEN
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DOENCAS DESMIELINIZANTES [Subject descriptor]
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Id:
18389
Author:
Rambukkana, Anura
Title:
Mycobacterium leprae-induced demyelination: a model for early nerve degeneration ..-
Source:
s.l; s.n; 2004. 7 p. ilus.
Abstract:
The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstratation of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration (AU).
Descriptors:
DOENCAS DESMIELINIZANTES/etiol
DOENCAS DESMIELINIZANTES/imunol
DOENCAS DESMIELINIZANTES/microbiol
DOENCAS DESMIELINIZANTES/patol
MYCOBACTERIUM LEPRAE/quim
MYCOBACTERIUM LEPRAE/cresc
MYCOBACTERIUM LEPRAE/patogen
-
DEGENERACAO NEURAL/etiol
DEGENERACAO NEURAL/patol
HANSENIASE/compl
HANSENIASE/imunol
HANSENIASE/microbiol
HANSENIASE/patol
Limits:
HUMANO
Location:
BR191.1; 09300/s
2 / 13
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Id:
13208
Author:
Job, C. K
Title:
Mechanism of nerve destruction in tuberculoid-borderline leprosy ..-
Source:
s.l; s.n; sep. 1973. 14 p. ilus.
Abstract:
The ultrastructural changes in radial cutaneous nerve biopsies from 3 tuberculoid and 14 tuberculoid-borderline patients were studied. In tuberculoid leprosy the nerve parenchyma was almost entirely replaced by tuberculoid granuloma. In nerves from borderline-tuberculoid leprosy many axons showed segmental demyelination and Wallerian degeneration. The nerve tissue was gradually replaced by proliferating collagen fibrils and inflammatory granulomata. M. leprae were rare and when present they were found in phagolysosomes of Schwann cells and macrophages. Schwann cells were surrounded and occasionally infiltrated by lymphocytes and macrophages. It was suggested that "sensitized Schwann cells" were the target of a hypersensivity reaction resulting in their degeneration or death which in turn produced segmental demyelination or Wallerian degeneration.(AU).
Descriptors:
HANSENIASE/imunol
HANSENIASE/microbiol
HANSENIASE/patol
DOENCAS DESMIELINIZANTES
ANTIGENOS DE BACTERIAS
MICROSCOPIA ELETRÔNICA
MYCOBACTERIUM LEPRAE/isol
NERVOS PERIFERICOS/patol
CELULAS DE SCHWANN
Limits:
HUMANO
Electronic Medium:
http://www.ilsl.br
Location:
BR191.1; 02021/s
3 / 13
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Id:
13203
Author:
Swift, Thomas R
Title:
Peripheral nerve involvement in leprosy: quantitative histologic aspects ..-
Source:
s.l; s.n; 1974. 8 p. tab, graf, ilus.
Abstract:
1. Nerve biopsies in three lepromatous and three dimorphous leprosy patients are reported. Bacilli were found in all three lepromatous nerves, and in one dimorphous nerve. Bacilli were present in cutaneous nerve twigs in all six patients. 2. Myelinated fiber counts were severly reduced in four patients. Large fibers were affected to a greater extent than small fibers. 3. Evidence of widespread segmental demyelination with remyelination was present. Wallerian degeneration was not found. 4. Schwann cell involvement with subsequent segmental demyelination appears to be an important event in the pathogenesis os leprous neuritis.(AU).
Descriptors:
CONTAGEM DE CELULAS
DOENCAS DESMIELINIZANTES/patol
HANSENIASE/compl
HANSENIASE/microbiol
HANSENIASE/patol
MYCOBACTERIUM LEPRAE
FIBRAS NERVOSAS MIELINIZADAS
DOENCAS DO SISTEMA NERVOSO PERIFERICO/microbiol
DOENCAS DO SISTEMA NERVOSO PERIFERICO/patol
PELE/inerv
HANSENÍASE DIMORFA / complicações
HANSENÍASE VIRCHOWIANA/complicações
SISTEMA NERVOSO PERIFÉRICO/lesões
SISTEMA NERVOSO PERIFÉRICO/ patologia
Limits:
HUMANO
ADULTO
IDOSO
FEMININO
MASCULINO
MEIA-IDADE
Electronic Medium:
http://www.ilsl.br
Location:
BR191.1; 02016/s
4 / 13
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Id:
13201
Author:
Dayan, A. D; Sandbank, U
Title:
Pathology of ther peripheral nerves in leprosy: report of a case ..-
Source:
s.l; s.n; oct. 1970. 6 p. ilus, graf.
Abstract:
Peripheral nerve trunks were examined from a case of lepromatous leprosy. M. leprae was seen in the nerves in several types of cells. isolated nerve fibre preparations showed demyelinating lesions due to Schwann cell damage and complete nerve fibre degeneration. The causes of this mixed pattern of damage may involve both a direct effect of the bacilli on nerve fibres and various epiphenomena.(AU).
Descriptors:
DOENCAS DESMIELINIZANTES/patol
HANSENIASE/patol
NERVO FEMORAL/patol
AUTOPSIA
NERVOS PERIFERICOS/patol
CELULAS DE SCHWANN
NERVO CIATICO/patol
DEGENERACAO NEURAL
NERVO ULNAR/patol
REGENERACAO NERVOSA
Limits:
HUMANO
IDOSO
MASCULINO
Electronic Medium:
http://www.ilsl.br
Location:
BR191.1; 02018/s
5 / 13
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Id:
12312
Author:
Brophy, Peter J
Title:
Subversion of Schwann cells and the leper's bell ..-
Source:
s.l; s.n; May 2002. 2 p. ilus.
Descriptors:
AXONIOS
MORTE CELULAR
DIFERENCIAÇAO CELULAR
MEMBRANA CELULAR
COCULTURA
PROTEINAS CITOESQUELETO
DOENÇAS DESMIELINIZANTES
DISTROFINA
GLICOLIPIDIOS
LAMININA
HANSENIASE
HANSENIASE
HANSENIASE
GLICOPROTEINAS DE MEMBRANAS
PROTEINAS DA MEMBRANA
CAMUNDONGOS
MYCOBACTERIUM LEPRAE
MYCOBACTERIUM LEPRAE
MYCOBACTERIUM LEPRAE
BAINHA DE MIELINA
CÉLULAS DE SCHWANN
CÉLULAS DE SCHWANN
CÉLULAS DE SCHWANN
Limits:
ANIMAL
Location:
BR191.1; 08621/s
6 / 13
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Id:
12289
Author:
Sarno, Euzenir Nunes; Pessolani, Maria Cristina Vidal
Title:
Oldest and most feared disease ..-
Source:
s.l; s.n; Dec. 2000. 1 p. ilus.
Descriptors:
DOENÇAS DESMIELINIZANTES
HANSENIASE
HANSENIASE
HANSENIASE
MYCOBACTERIUM LEPRAE
CÉLULAS DE SCHWANN
CÉLULAS DE SCHWANN
FATOR DE NECROSE TUMORAL/PH
Location:
BR191.1; 08656/s
7 / 13
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Id:
12244
Author:
Rambukkana, Anura; Zanazzi, George; Tapinos, Nikos; Salzer, James L
Title:
Contact-dependent demyelination by mycobacterium leprae in the absence of immune cells ..-
Source:
s.l; s.n; May 2002. 5 p. ilus, graf.
Descriptors:
APOPTOSE
AXONIOS
AXONIOS
LINFOCITOS B
ADERENCIA BACTERIANA
DIVISAO CELULAR
COCULTURA
DOENÇAS DESMIELINIZANTES
GANGLIOS ESPINHAIS
GENES RAG-1
GLICOLIPIDIOS
HANSENIASE
HANSENIASE
HANSENIASE
HANSENIASE
MACROFAGOS
CAMUNDONGOS
CAMUNDONGOS ENDOGAMICOS C57BL
CAMUNDONGOS KNOCKOUT
MUTAÇAO
MYCOBACTERIUM LEPRAE
MYCOBACTERIUM LEPRAE
BAINHA DE MIELINA
BAINHA DE MIELINA
DEGENERAÇAO NEURAL
FIBRAS NERVOSAS MIELINIZADAS
NEURONIOS
CÉLULAS DE SCHWANN
CÉLULAS DE SCHWANN
NERVO CIATICO
NERVO CIATICO
LINFOCITOS T
CULTURA DE TECIDO
Limits:
ANIMAL
Location:
BR191.1; 08647/s
8 / 13
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Id:
11890
Author:
Ottenhoff, Tom H. M
Title:
Mycobacterium leprae and demyelination ..-
Source:
s.l; s.n; 2002. 2 p. .
Descriptors:
HANSENIASE
HANSENIASE
HANSENIASE
DOENÇAS DESMIELINIZANTES
DOENÇAS DESMIELINIZANTES
DOENÇAS DESMIELINIZANTES
MYCOBACTERIUM LEPRAE
CÉLULAS DE SCHWANN
Location:
BR191.1; 08572/s
9 / 13
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Id:
11749
Author:
Rambukkana, Amura; Zanazzi, George; Tapinos, Nikos; Salzer, James L
Title:
Contact-dependent demyelination by Mycobacterium leprae in the absence of immune cells ..-
Source:
s.l; s.n; 2002. 5 p. ilus.
Descriptors:
HANSENIASE
HANSENIASE
HANSENIASE
HANSENIASE
MYCOBACTERIUM LEPRAE
MYCOBACTERIUM LEPRAE
AXONIOS
AXONIOS
ADERENCIA BACTERIANA
DIVISAO CELULAR
COCULTURA
DOENÇAS DESMIELINIZANTES
GANGLIOS ESPINHAIS
GENES RAG-1
GLICOLIPIDIOS
MACROFAGOS
MUTAÇAO
BAINHA DE MIELINA
BAINHA DE MIELINA
DEGENERAÇAO NEURAL
-
FIBRAS NERVOSAS MIELINIZADAS
NEURONIOS
CÉLULAS DE SCHWANN
CÉLULAS DE SCHWANN
NERVO CIATICO
NERVO CIATICO
LINFOCITOS T
CULTURA DE TECIDO
Location:
BR191.1; 08525/s
10 / 13
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Id:
11744
Author:
Brophy, Peter J
Title:
Subversion of Schwann cells and the leper's Bell ..-
Source:
s.l; s.n; 2002. 2 p. ilus.
Descriptors:
HANSENIASE
HANSENIASE
HANSENIASE
MYCOBACTERIUM LEPRAE
MYCOBACTERIUM LEPRAE
MYCOBACTERIUM LEPRAE
AXONIOS
DIFERENCIAÇAO CELULAR
MEMBRANA CELULAR
COCULTURA
PROTEINAS CITOESQUELETO
DOENÇAS DESMIELINIZANTES
DISTROFINA
GLICOLIPIDIOS
LAMININA
GLICOPROTEINAS DE MEMBRANAS
BAINHA DE MIELINA
CÉLULAS DE SCHWANN
CÉLULAS DE SCHWANN
CÉLULAS DE SCHWANN
Location:
BR191.1; 08527/s
11 / 13
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Id:
10957
Author:
Hong, Seung-Mo; Ha, Hongil; Suh, Jae-Hee; Kim, Kwang-KukKhang, Shin Kwang; Ro, Jae Y; Park, Sung-Hye
Title:
Clinicopathologic analysis of 124 biopsy-proven peripheral nerve diseases ..-
Source:
s.l; s.n; 2000. 6 p. ilus, tab.
Descriptors:
BIOPSIA
DOENÇA DE CHARCOT-MARIE
DOENÇAS DESMIELINIZANTES
DOENÇA DE FABRY
NEUROPATIAS MOTORAS E SENSORIAIS HEREDITARIAS
CORÉIA (GEOGRAFICO)
HANSENIASE
MICROSCOPIA ELETRONICA
FIBRAS NERVOSAS MIELINIZADAS
NERVOS PERIFÉRICOS
NERVOS PERIFÉRICOS
DOENÇAS DO SISTEMA NERVOSO PERIFÉRICO
DOENÇAS DO SISTEMA NERVOSO PERIFÉRICO
NERVO SURAL
NERVO SURAL
Location:
BR191.1; 07436/s
12 / 13
HANSEN
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Id:
9821
Author:
Suneetha, Lavanya M; Korula, Ravi Jacob; Balasubramanian, A. S
Title:
Protein phosphorylation in human peripheral nerve: altered phosphorylation of a 25-kDa glycoprotein in leprosy ..-
Source:
s.l; s.n; 1996. 6 p. ilus.
Descriptors:
DOENÇAS DESMIELINIZANTES
ESTUDOS DE CASOS E CONTROLES
GLICOPROTEINAS
HANSENIASE
Location:
BR191.1; 06727/s
13 / 13
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Id:
9749
Author:
Said, Gerard
Title:
Inflammatory neuropathies associated with known infections (HIV, leprosy, Chagas disease, Lyme disease) ..-
Source:
s.l; s.n; 1994. 23 p. ilus.
Descriptors:
HANSENIASE TUBERCULOIDE
HANSENIASE TUBERCULOIDE
NERVOS PERIFÉRICOS
BIOPSIA
DOENÇA DE CHAGAS
DOENÇA DE CHAGAS
DOENÇAS DESMIELINIZANTES
DOENÇAS DESMIELINIZANTES
INFECÇOES POR HIV
INFECÇOES POR HIV
HIV-1
HIV-2
DOENÇA DE LYME
DOENÇA DE LYME
Location:
BR191.1; 06700/s
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